Our NIH-funded laboratory at Washington University in St. Louis is seeking a highly-motivated postdoctoral research associate. The Rosen lab studies Klebsiella pneumoniae pathogenesis, virulence and immune response. This increasingly resistant pathogen frequently causes pneumonia, sepsis and urinary tract infection in hospitalized patients. We are interested in the host immune response to Klebsiella pneumoniae. Specifically, we are identifying important antigenic proteins presented by the bacterium and the milieu of host cells (T cell subsets, etc…) responsible for responding to this organism, both in acute and adaptive models of infection. We are the first and only lab to publish on a nonlethal model of Klebsiella respiratory tract infection in which survivors are fully protected from subsequent challenge--allowing for mechanistic studies of adaptive immunity.
We are seeking an immunologist to join our lab family. Some specific projects include: 1) characterization of T cell subsets, including gamma-delta T cells, imperative in mounting a protective response to Klebsiella. 2) characterization of the humoral immune response, seeking universal antigenic Klebsiella proteins as vaccine candidates. 3) Analyzing the host response and efficacy of our prototype bioconjugate vaccine against hypervirulent Klebsiella.
We utilize numerous technical modalities, including flow cytometry, cloning, protein and DNA-based molecular biology, ELISAs, biochemistry, cell/tissue culture, fluorescence and confocal microscopy, and DNA/RNA sequencing. Additionally, we employ numerous murine models of Klebsiella infection.
Preferred qualifications include:
- Experience with immunologic assays including flow cytometry, ELISAs, and/or Elispots.
- Knowledge of Gamma-delta T cells and TH17 pathways
- Interest in Vaccines and Efficacy Experiments
For additional details, visit: http://research.peds.wustl.edu/labs/rosen_d.
In addition to high-quality research facilities at Washington University, career and professional development training for postdoctoral researchers is provided through the Office of Postdoctoral Affairs, Career Center, Teaching Center, Writing Center and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.
Location/Region: Saint Louis, MO (63110)